VAN DER WOUDE SYNDROME
van der Woude syndrome is an autosomal dominant syndrome consisting of a cleft lip / cleft palate in association with lower lip pits.
The pits constantly secrete mucous and the discharge is very embarrassing for the patient.
Chromosomal studies show deletions in the chromosomes at 1q32 . A modifying gene may also be responsible which is located at 17p11.
Some extraoral manifestations like limb anomalies, popliteal webs, and brain abnormalities are also reported.
Very rare cases with accessory nipples, congenital heart defects, and Hirschprung disease are also seen.
Surgical removal of pits can be carried out for cosmetic reasons.
Pevious Topic: Facial Hemiatrophy
Next Topic : Congenital Lip and Commisural Pits and Fistulas