Oral Submucous Fibrosis Recent Advances 2009

 In Vivo OSF Treatment Effectiveness Detection by Autofluorescence

Autofluorescence is the latest technique to assess the effectiveness of treatment in Oral Submucous Fibrosis (OSF). When tissues interact with light they emit back a light in minute quantities, known as autofluorescence. It can be detected with highly sensitive spectrophotometres. Normal mucosa shows emissions in different spectral range than the fibrosed mucosa. In cases that responded to the treatment showed emission spectrum similar to that of normal mucosa. The greatest advantage of this test is that it can be performed invivo , it is non invasive and does not show any related adverse effects.
Ref: Vedeswari CP, Jayachandran S, Ganesan S. In vivo autofluorescence characteristics of pre- and post-treated oral submucous fibrosis: A pilot study. Indian J Dent Res [serial online] 2009 [cited 2009 Dec 16];20:261-7. Available from: http://www.ijdr.in/text.asp?2009/20/3/261/57354

This Red Dye Writes About Oral Submucous Fibrosis In Greater Detail

Various dyes are used for staining sections of Oral Submucous Fibrosis (OSF). Picrosirius red stain under polarizing microscopy shows staining the finer fibres and correlation with clinicofunctional staging.
Ref: Ceena DE, Bastian TS, Ashok L, Annigeri RG. Comparative study of clinicofunctional staging of oral submucous fibrosis with qualitative analysis of collagen fibers under polarizing microscopy. Indian J Dent Res [serial online] 2009 [cited 2009 Dec 16];20:271-6. Available from: http://www.ijdr.in/text.asp?2009/20/3/271/57356

Efficacy Of Licopene In Management Of Oral Submucous Fibrosis

Background And Objective: OSMF is an avancing premalignant condition for which a reliable treatment modality has not yet evolved. The aim of the present study was to evaluate the efficacy of newer anti-oxidant - Lycopene in the treatment of OSMF.

Material And Methods: The study group included 50 patients with OSMF. The diagnosis of OSMF was established thrugh a composite of clinical and histopathologic characteristics. Out of 50 patients, 25 were given licopene (8 mg Lycored/ day in divided doses of 4 mg each for a period of 3 months. Remaining patients recieved placeo tablets twice a day. Patients were examined for changes in mouth opening and oter symptoms of OSMF during 3 months and were followed for the next 2 months.

Results: Lycopene was found to be significantly effeficaious in the amelioration of signs and symptoms of OSMF. It was also effective in reducing the objective signs of OSMF as demonstrated by the improved maximal mouth opening, ercentage of which was 69.56 (p<0.05).

Conclusion: Reactive oxygen compounds or free radicals have been implicated as one of the major harmful sector for premalignant and malignant conditions. Our study concludes that lycopene appears to be very promising drug in the management of OSMF.

Author Dr. Rajeev Sharma (standing left)

Co-Author Dr. Durgesh Bailoor (standing left)

The Effect Of Anti-Retroviral Therapy On The Prevalence Of Oral Manifestation In HIV Sero Positive Patients

Background & Objectives: Acquired immunodeficiency syndrome (AIDS) is a highly lethal, progressively epidemic viral infection characterized by profound impairment of the immune system. According to the Center for Disease Control and Prevention’s (CDC) new classification system, clinical AIDS is defined by a CD4 count of less than 200 (<200) and / or a CD4 percentage of less than 14. The main objective of the current study was to determine the prevalence of oral manifestation of HIV patients on Highly Active Antiretroviral Therapy (HAART) and to compare these with the prevalence of those who were not on (HAART) therapy.
 Methods: Patients were selected from the out patient department of P.M.N.M dental college and hospital Bagalkot and patients from NGOs centers working for HIV/AIDS, Karnataka. A cross sectional was conducted amongst 100 patients diagnosed as HIV sero positive. Information regarding, date of birth, CD4 cell count were obtained from the medical records. Oral examination was done using universal precautions recommended by (CDC). Findings were recorded by using internationally accepted presumptive clinical criteria. Chi-square statistical test were conducted to describe the relationship between the prevalence of Oral manifestation and HAART therapy
Results: The detection of oral manifestation was significantly decreased in subjects on HAART therapy (32%) compared to those who were not on HAART therapy (56%), (P<0.05).
Interpretation & Conclusion:  Compared to non-HAART group, subjects on HAART group had significantly fewer HIV related oral manifestations-probably as a result of an expression of their reconstituted immune system.
By: Dr. Neelkant Patil

What Does This Radiograph Reveal ?

A 37 year old, male patients reported to Department Of OMR, JDC, with the complaint of pain in back region of the jaw. History revealed that he did not use the affected side of the jaws for more than 4 years. It was clinically found that the pain is because of chronic pulpitis in his third molar. A radiograph was also taken.
The radiograph shows an extra radio-opaque mass attached to the distal surface of the crown of third molar.
The question here is to make the most probable diagnosis about the radiopaque mass.
Please write down your answers in the comments section.